AADR Science Advocate - 11/10/2011  (Plain Text Version)

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In this issue:
•  JDR November Issue Now Online
•  JDR Hot Topics
•  Read the Science Advocate on Your Mobile Device
•  Stay in the Know, Read the AADR Government Affairs Blog
•  IADR/AADR Publish Study on Obesity Link to Periodontitis
•  NIH Loan Repayment Programs
•  Webinar Series: President's Initiative on University Research Commercialization
•  AADR Member Cun-Yu Wang Elected to the Institute of Medicine
•  IADR/AADR Publish Study on Dental Caries Vaccine
•  AADR Strides in Science
•  2012 Awards and Fellowships
•  Transformative Research Award Program
•  NIH Funding Announcements
•  Free Training in Dental Informatics (MS/PhD/postdoctoral positions)
•  AAMC Calls for Proposals for Oral Health in Medicine Model Curriculum
•  Immunopathogenesis of HIV/AIDS-related Oral Manifestations and Host Immunity (R01 and R21)
•  NIH Launches Medical Research Scholars Program
•  Register to Attend the 2012 AADR/CADR Annual Meeting
•  10th Gordon Research Conference on the Biology of Spirochetes
•  New Research Opportunities Available at the IADR/AADR Online Career Center

 

IADR/AADR Publish Study on Dental Caries Vaccine

In a report on a preclinical investigation titled “Flagellin Enhances Saliva IgA Response and Protection of Anti-caries DNA Vaccine,” lead author Wei Shi, Wuhan Institute of Virology, Chinese Academy of Sciences, and his team of researchers demonstrate that anti-caries DNA vaccines, including pGJA-P/VAX, are promising for preventing dental caries.

In a report on a preclinical investigation titled “Flagellin Enhances Saliva IgA Response and Protection of Anti-caries DNA Vaccine,” lead author Wei Shi, Wuhan Institute of Virology, Chinese Academy of Sciences, and his team of researchers demonstrate that anti-caries DNA vaccines, including pGJA-P/VAX, are promising for preventing dental caries. However, challenges remain because of the low immunogenicity of DNA vaccines. This study is published in the Journal of Dental Research, the official publication of the International and American Associations for Dental Research (IADR/AADR).

In this study, Shi and team used recombinant flagellin protein derived from Salmonella as mucosal adjuvant for anti-caries DNA vaccine (pGJA-P/VAX) and analyzed the effects of Salmonella protein on the serum surface protein immunoglobulin G and saliva surface protein immunoglobulin A antibody responses, the colonization of Streptococcus mutans (S. mutans) on rodent teeth, and the formation of caries lesions. The results showed that Salmonella promoted the production of surface protein immunoglobulin G in serum and secretory immunoglobulin A in saliva of animals by intranasal immunization with pGJA-P/VAX plus Salmonella.

Furthermore, Shi found that enhanced surface protein immunoglobulin A responses in saliva were associated with inhibition of S. mutans colonization of tooth surfaces and endowed better protection with significant less carious lesions. In conclusion, the study demonstrates that recombinant Salmonella could enhance specific immunoglobulin A responses in saliva and protective ability of pGJA-P/VAX, providing an effective mucosal adjuvant candidate for intranasal immunization of an anti-caries DNA vaccine.

Daniel Smith, The Forsyth Institute, wrote a corresponding perspective article in response to the Shi et al report titled “Prospects in Caries Vaccine Development.” In it, he states that DNA vaccine approaches for dental caries have had a history of success in animal models. Dental caries vaccines, directed to key components of S. mutans colonization and enhanced by safe and effective adjuvants and optimal delivery vehicles, are likely to be forthcoming.

“These papers highlight the exciting potential of using vaccines to protect against dental caries,” said JDR Editor-in-Chief (and AADR member) William Giannobile. “This research is promising and provides optimism to help promote public health of caries-susceptible individuals.”  

Visit http://jdr.sagepub.com/content/early/recent for links to the complete articles.