August 1, 2007

In the IDSA Journals

Avian Influenza Virus Infection in Veterinarians

In this case-control study, the health of patients with botulism was evaluated >6 months after illness. Those who had previously had botulism were substantially more likely than control subjects to report fatigue, generalized weakness, dizziness, dry mouth, difficulty lifting things, and difficulty breathing with moderate exertion.(Myers et al., Clin Infect Dis. 2007;45:4-9.)

Ionization, Fungi, and Health Care Water Supplies

In a study ofthe hot and coldpotable water supplies ofSpanish health care centers,the prevalence of fungiwas significantly lower insystems using copper- orsilver-ionized water than insystems using nonionized water. (Pedro-Botet et al.,Clin Infect Dis. 2007;45:84-86.) 

Long-term Outcomes of Botulism 

In this case-control study,the health of patientswith botulism was evaluated>6 months after illness.Those who had previouslyhad botulism were substantiallymore likely than controlsubjects to report fatigue,generalized weakness, dizziness, drymouth, difficulty lifting things,and difficulty breathing withmoderate exertion. (Gottlieb et al., Clin Infect Dis. 2007;45:174-180.)

 botulism emotion CID title

Genetic Factors Linked to Fever Following Smallpox Vaccination

New evidence supports the link between genetic factors and certain adverse events related to smallpox vaccination.  The study may have implications for predicting adverse events from other live vaccines. Researchers studied 346 individuals who had participated in previous smallpox vaccination trials, 94 of whom developed fevers after vaccination.  The authors identified a total of eight haplotypes in four different genes that were associated with altered susceptibility to fever after vaccination. (Stanley et al., J Infect Dis.2007;196:212-219.)

New Data on Transmission, Malignancy of Human Herpesvirus 8 (HHV-8)

In a study examining 13,894 adults in the National Health andNutrition Examination Survey III, researchers found transmission of HHV-8 (also known as Kaposi sarcoma-associated herpesvirus) in men linked to sexual activity, especially male-to-male sexual activity, but not linked to heterosexual transmission to women. (Engles et al., J Infect Dis. 2007;196:199-207.) A second study found HHV-8 was not a major cause of prostate cancer, disputing the conclusions of a previous study that had found elevated levels of HHV-8 antibodies in men with prostate cancer. (Jenkins et al., J Infect Dis 2007;196:208-211.)

Altered Gene Expression in Postinfective Fatigue Syndrome (PIFS)

In a unique, prospective, population-based study that may open doors to better understanding of chronic fatigue syndrome, the authors examined changes in gene expression in patients who developed PIFS following Epstein-Barr virus infection. They identified 35 gene expression changes that correlated with the course of PIFS. These genes had not previously been linked to PIFS and included genes involved insignal transduction pathways, metalion binding, and ionchannel activity. (Cameron et al., J Infect Dis.2007;196:56-66.)

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